Last reviewed: November 2017
Last updated: July  2016

Summary

Definition

History and exam

Key diagnostic factors

  • fatigue
  • weakness
  • lethargy
  • arthralgias
  • hepatomegaly
  • diabetes mellitus
  • impotence in males
  • loss of libido
  • skin pigmentation

Other diagnostic factors

  • congestive heart failure
  • arrhythmias
  • porphyria cutanea tarda

Risk factors

  • middle age
  • male gender
  • white ancestry
  • family history
  • supplemental iron

Diagnostic investigations

1st investigations to order

  • serum transferrin saturation
  • serum ferritin
Full details

Investigations to consider

  • HFE mutation analysis
  • MRI liver
  • liver biopsy
  • LFTs
  • fasting blood sugar
  • echocardiogram
  • ECG
  • testosterone, FSH, and LH assays
  • bone densitometry
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Associate Professor of Internal Medicine

University of Iowa Carver College of Medicine

Iowa City

IA

Disclosures

KEB declares that she has no competing interests.

Dr Kyle E. Brown would like to gratefully acknowledge Dr Rebecca Fischer Connor, the previous contributor to this monograph. RFC declares that she has no competing interests.

Peer reviewers VIEW ALL

Professor of Medicine and Chief of Liver Disease Department

University Hospital Pontchaillou

Rennes

France

Disclosures

PB declares that he has no competing interests.

Associate Professor

Department of Family Medicine

University of Wisconsin

Madison

WI

Disclosures

WEC declares that he has no competing interests.

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