Last reviewed: November 2017
Last updated: February  2017

Summary

Definition

History and exam

Key diagnostic factors

  • dysphagia
  • food avoidance and modification behaviors

Other diagnostic factors

  • heartburn
  • chest discomfort
  • nausea/vomiting
  • regurgitation
  • abdominal pain
  • failure to thrive
  • irritability

Risk factors

  • family history of eosinophilic esophagitis (EoE)
  • male gender
  • atopic disease
  • children and younger adults
  • white ancestry

Diagnostic investigations

1st investigations to order

  • esophagogastroduodenoscopy (EGD)
  • esophageal biopsy
  • proton-pump inhibitor (PPI) trial
  • CBC with differential
Full details

Emerging tests

  • transnasal endoscopy
  • esophageal string test (EST)
  • cytosponge
  • mucosal impedance
  • EoE diagnostic panel (EDP)
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Associate Professor of Medicine and Epidemiology

Center for Esophageal Diseases and Swallowing

Center for Gastrointestinal Biology and Disease

Division of Gastroenterology and Hepatology

Department of Medicine

University of North Carolina School of Medicine

Chapel Hill

NC

Disclosures

ESD is an author of a number of references cited in this monograph.

Peer reviewers VIEW ALL

Professor of Medicine

Mayo Clinic

Rochester

MN

Disclosures

DK has served on advisory boards (Adare, Receptos) and received research funding (Covidien).

Honorary Professor

Chief of the Division of Gastroenterology and Hepatology

First Department of Pediatrics

University of Athens

Agia Sofia Children’s Hospital

Athens

Greece

Disclosures

AP has received speaker’s honorariums from Nestle and Nutricia; research grants from Biogaia/Nutricia/Abbvie; consultant’s fee from Receptos.

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