Last reviewed: November 2017
Last updated: April  2017

Summary

Definition

History and exam

Key diagnostic factors

  • fever
  • malaise
  • nausea and vomiting
  • jaundice
  • hepatomegaly
  • RUQ pain
  • clay-colored stools

Other diagnostic factors

  • fatigue
  • headache
  • dark urine
  • pruritus
  • arthralgias and myalgias
  • cough
  • diarrhea
  • constipation
  • splenomegaly
  • posterior cervical lymphadenopathy
  • evanescent rash
  • bradycardia

Risk factors

  • living in endemic region
  • close personal contact with an infected person
  • men who have sex with men
  • travel outside the US
  • illicit drug use
  • known foodborne outbreak
  • contact with a child or employee in a childcare center

Diagnostic investigations

1st investigations to order

  • serum aminotransferases
  • serum bilirubin
  • BUN
  • serum creatinine
  • prothrombin time
  • IgM anti-hepatitis A virus (HAV)
Full details

Investigations to consider

  • IgG anti-hepatitis A virus (HAV)
  • electron microscopy of stool and body fluids
  • Hepatitis A virus RNA detection
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Fida A. Khan

Infectious Diseases Attending

Seton Medical Center Williamson

Round Rock

TX

Disclosures

FAK declares that he has no competing interests.

Hospitalist Physician

Archbold Memorial Hospital

Thomasville

GA

Assistant Clinical Professor

Florida State University School of Medicine

Tallahassee

FL

Disclosures

MW declares that he has no competing interests.

Peer reviewers VIEW ALL

Professor of Medicine and Cell Biology

Columbia University College of Physicians and Surgeons

New York

NY

Disclosures

HJW declares that he has no competing interests.

Gastroenterologist

Dartmouth-Hitchcock Nashua

Nashua

NH

Disclosures

SN declares that he has no competing interests.

Professor of Medicine

University of Connecticut Health Center

Farmington

CT

Disclosures

GYW is on the medical advisory boards of the following: Gilead Sciences, Bristol-Myers Squibb, AbbVie, and Intercept.

Assistant Professor

Division of Gastroenterology

Department of Medicine

Brown University

RI

Disclosures

KP declares that he has no competing interests.

Professor

Director of Vaccine & Infectious Disease Institute

University of Antwerp

Antwerp

Belgium

Disclosures

PVD has been and still is principal investigator of vaccine trials for several vaccine manufacturing companies, from which the university obtained and obtains research contracts and funds for conducting such vaccine trials.

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