Last reviewed: November 2017
Last updated: April  2017

Summary

Differentials

Common

  • Purpura simplex
  • Senile purpura
  • Medications
  • Alcohol abuse
  • Drug-induced thrombocytopenia
  • Platelet storage pool disease
  • von Willebrand disease
  • Vitamin K deficiency
  • Cirrhosis
  • Vasculitis

Uncommon

  • Hereditary hemorrhagic telangiectasia (HHT)
  • Cushing syndrome
  • Child abuse
  • Elder abuse
  • Immune thrombocytopenia (ITP)
  • Thrombotic thrombocytopenic purpura (TTP)
  • Hemolytic uremic syndrome (HUS)
  • Disseminated intravascular coagulation (DIC)
  • Wiskott-Aldrich syndrome
  • MYH9-related disorders
  • Bernard-Soulier disease
  • Thrombocytopenia with absent radius (TAR) syndrome
  • Glanzmann thrombasthenia
  • Acute myelogenous leukemia
  • Acute lymphocytic leukemia
  • Hodgkin lymphoma
  • Non-Hodgkin lymphoma
  • Multiple myeloma
  • Solid tumor with infiltration of bone marrow
  • Myelofibrosis
  • Myelodysplastic syndrome
  • Aplastic anemia
  • Hemophilia
  • Factor V, VII, X, or XI deficiency
  • Acquired coagulation inhibitors
  • Vitamin C deficiency
  • Marfan syndrome
  • Ehlers-Danlos syndrome
  • Acute liver failure
  • Gardner-Diamond syndrome

Contributors

Authors VIEW ALL

Tzu-Fei Wang

Assistant Professor of Internal Medicine

The Ohio State University

Columbus

OH

Disclosures

TW declares that she has no competing interests.

Eric H. Kraut

Professor of Internal Medicine

The Ohio State University

Columbus

OH

Disclosures

EHK declares that he has no competing interests.

Peer reviewers VIEW ALL

Associate Professor

Department of Medicine

McMaster University

Hamilton

Ontario

Canada

Disclosures

DMA has received speaking honoraria from Amgen for presentation on immune thrombocytopenia; consulting fees from Amgen, and Bristol-Myers Squibb for ITP related studies; and research grants from Amgen, GlaxoSmithKline, and Hoffman-La Roche for clinical studies in ITP. He is co-author of a reference cited in this monograph.

Clinical Scholar

McMaster University

St. Joseph’s Healthcare Hamilton

Hamilton

Ontario

Canada

Disclosures

DS declares that she has no competing interests.

Assistant Professor of Pediatrics

Nationwide Children’s Hospital

Ohio State University

Columbus

OH

Disclosures

RK declares that he has no competing interests.

Consultant Haematologist

Oxford Haemophilia & Thrombosis Centre

Churchill Hospital

Oxford

UK

Disclosures

DK declares that he has no competing interests.

Professor of Haematology

University of Liverpool

Liverpool

UK

Disclosures

CHT declares that he has no competing interests.

Consultant Haematologist

Heart of England NHS Foundation Trust

Birmingham

UK

Disclosures

SP has received a speaker fee from Janssen.

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