Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • residence in/travel from dengue-endemic region within the past 2 weeks
  • fever
  • skin flushing/rash
  • myalgia/arthralgia/headache
  • hemorrhagic signs
  • lethargy/restlessness
  • hepatomegaly
  • abdominal distention
  • pleuritic chest pain, dyspnea, cough
  • signs of circulatory collapse

Other diagnostic factors

  • gastrointestinal symptoms
  • upper respiratory tract symptoms

Risk factors

  • residence in/travel from dengue-endemic region within the past 2 weeks
  • children ages 1 to 5 years
  • older people
  • pregnancy
  • exposure to infected blood products
  • female gender
  • obesity
  • presence of comorbidities

Diagnostic investigations

1st investigations to order

  • CBC
  • LFTs
  • serum albumin level
  • serology
  • reverse transcription-polymerase chain reaction (RT-PCR)
  • nonstructural protein 1 (NS1) detection
Full details

Investigations to consider

  • coagulation studies
  • chest x-ray
  • abdominal ultrasound
Full details

Emerging tests

  • reverse transcription-insulated isothermal polymerase chain reaction (RT-iiPCR)
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

S.A.M. Kularatne

Senior Professor

Chair of Medicine

Department of Medicine

Faculty of Medicine

University of Peradeniya

Peradeniya

Sri Lanka

Disclosures

SAMK is an author of several references cited in this monograph.

Peer reviewers VIEW ALL

Professor of Medicine

James Cook University

Cairns Base Hospital Clinical School

Cairns

Australia

Disclosures

JM declares that he has no competing interests.

Consultant

Infectious Diseases

Royal Free Hampstead NHS Trust

London

UK

Disclosures

MJ declares that he has no competing interests.

Professor of Medicine

Medical Director

Penn Global Medicine

Penn Center for Primary Care

PA

Disclosures

SG declares that he has no competing interests.

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