Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • occupational exposure to sensitizing agents or irritants
  • symptoms of asthma that improve during holidays
  • initial onset of asthma symptoms during a work period

Risk factors

  • high-level exposure to sensitizer
  • atopy
  • genetic factors
  • smoking

Diagnostic investigations

1st investigations to order

  • spirometry (pre- and post-bronchodilator)
  • chest x-ray
  • skin prick testing
  • specific serum IgE assay
  • nonspecific bronchial provocation testing
  • serial peak expiratory flow rate
Full details

Investigations to consider

  • specific inhalation challenge
Full details

Emerging tests

  • induced sputum cytology
  • exhaled nitric oxide
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Ryan Hoy

Respiratory Physician

The Alfred Hospital

Melbourne

Victoria

Australia

Disclosures

RH declares that he has no competing interests.

Susan M. Tarlo

Professor of Medicine

University of Toronto

Respiratory Physician

Toronto Western Hospital

Toronto

Ontario

Canada

Disclosures

SMT has performed medical assessments of patients at the request of the Ontario Workplace Safety and Insurance Board (the Ontario workers' compensation system), for which payments were made to her institution. She has also received research grant support from the Ontario Workplace Safety and Insurance Board.

Peer reviewers VIEW ALL

Associate Professor of Medicine

Stanford University

Stanford

Staff Physician

US Department of Veterans Affairs

Palo Alto Health Care System

Palo Alto

CA

Disclosures

WK declares that he has no competing interests.

Associate Professor of Medicine

National Jewish Medical Centre

Denver

CO

Disclosures

KP declares that she has no competing interests.

Professor of Medicine

University of California

Los Angeles

CA

Disclosures

PH declares that he has no competing interests.

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