Last reviewed: November 2017
Last updated: October  2017

Summary

Definition

History and exam

Key diagnostic factors

  • acute to subacute recurrent skin eruption
  • polymorphic, generalized, nonpruritic skin eruption

Other diagnostic factors

  • scars or pigment changes
  • immunosuppression
  • recent illness
  • FHx of pityriasis lichenoides
  • headache
  • myalgias/arthralgias
  • malaise
  • burning/pruritus
  • multiorgan failure

Risk factors

  • childhood to early adult age
  • male gender
  • HIV

Diagnostic investigations

1st investigations to order

  • dermoscopy
  • skin biopsy
Full details

Investigations to consider

  • antistreptolysin titers
  • EBV IgM/IgG viral capsid antigen and nuclear antigen antibody
  • monospot or heterophil antibody test
  • hepatitis B surface antigen, antisurface antibody, and anticore IgM
  • hepatitis C virus antibody
  • HIV screening
  • rapid plasma reagin
  • throat cultures
  • toxoplasma Sabin-Feldman dye test, indirect immunofluorescence/hemagglutination
  • ESR
  • CRP
  • serum LDH
  • WBC count
  • serum albumin
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Clinical Instructor in Dermatology

SUNY Downstate Medical Center

Brooklyn

NY

Disclosures

AK declares that he has no competing interests.

Dermatology Faculty

Department of Dermatology & Cutaneous Surgery

University of Miami

Miami

FL

Disclosures

MB-K declares that she has no competing interests.

Peer reviewers VIEW ALL

Resident

Department of Dermatology

Wake Forest University School of Medicine

Winston-Salem

NC

Disclosures

ADL declares that he has no competing interests.

Assistant Professor

King Fahd University of Petroleum and Minerals

Dhahran

Saudi Arabia

Disclosures

AS declares that he has no competing interests.

Use of this content is subject to our disclaimer