A leading cause of morbidity and mortality.
Approximately 85% of strokes are ischemic, caused by vascular occlusion.
A clinical emergency: timely diagnosis, triage, and intervention can improve outcome.
Care of patients in dedicated stroke units improves survival and function.
Intravenous recombinant tissue plasminogen activator (r-tPA) is given within 4.5 hours of stroke onset.
Endovascular interventions, such as clot retrieval devices or intra-arterial thrombolysis, can be used in carefully selected patients within 6 hours of ischemic stroke onset.
Stroke is defined as an acute neurologic deficit lasting >24 hours and caused by cerebrovascular etiology. It is further subdivided into ischemic stroke (caused by vascular occlusion or stenosis) and hemorrhagic stroke (caused by vascular rupture, resulting in intraparenchymal and/or subarachnoid hemorrhage). Central venous sinus thrombosis is a rare form of stroke that occurs due to thrombosis of the dural venous sinuses. This monograph deals with ischemic stroke.
Transient ischemic attack (TIA) is defined as a transient episode of neurologic dysfunction caused by focal brain, spinal cord, or retinal ischemia, without acute infarction. Patients with TIAs are at high risk for early ischemic stroke,  and their risk may be stratified by clinical scale, vessel imaging, and diffusion magnetic resonance imaging.  This replaced the former definition of focal neurologic impairment lasting less than 24 hours.
Assistant Professor of Internal Medicine
University of Thessaly
Hellenic Stroke Organization
Larissa University Hospital
GN is one the advisory boards for, and has received honoraria, speaker fees, and research support from: Amgen; Bayer; Boehringer-Ingelheim; BMS/Pfizer; Elpen; Galenica; Medtronic; Sanofi; and Winmedica.
Dr George Ntaios would like to gratefully acknowledge Dr Alireza Minagar, a previous contributor to this monograph. AM declares that he has no competing interests.
Centre Hospitalier Universitaire Vaudois (CHUV)
JM declares that he has no competing interests.
Lecturer in Neurology
Beth Israel Deaconess Medical Center
Division of Cerebrovascular/Stroke
LRC declares that he has no competing interests.
National Clinical Director
Stroke NHS England
Professor, Stroke Medicine
Kings College London
Chair, Intercollegiate Stroke Working Party
Royal College of Physicians
TR declares that he has no competing interests.
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