Last reviewed: November 2017
Last updated: December  2016

Summary

Definition

History and exam

Other diagnostic factors

  • tachycardia
  • tachypnea
  • hypotension
  • poor capillary refill
  • acute mental confusion
  • decreased urine output
  • low oxygen saturation
  • rash
  • hepatosplenomegaly
  • hypothermia

Risk factors

  • use of central venous catheter
  • exposure to broad-spectrum antibiotics
  • colonization at multiple sites
  • hemodialysis
  • surgery
  • parenteral nutrition
  • immunosuppressants (e.g., chemotherapy, systemic corticosteroids)
  • intravenous drug use

Diagnostic investigations

1st investigations to order

  • blood culture
  • CBC
  • ABG
  • lactate levels
  • coagulation studies
  • renal function tests
  • LFT
  • serum glucose
Full details

Investigations to consider

  • beta 1,3 glucan
  • T2 magnetic resonance assay
  • tissue biopsy
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Dean and Professor of Medicine

Wayne State University School of Medicine

Detroit

MI

Disclosures

JDS declares that he has no competing interests.

Professor of Medicine

Division of Infectious Diseases

Wayne State University School of Medicine

Detroit

MI

Disclosures

SR has received grants for research from Astellas, Gilead, and Merck, and is involved in clinical trials for Cidara.

Peer reviewers VIEW ALL

Professor of Medicine

Department of Medicine

Medical College of Georgia

Augusta

GA

Disclosures

JF is an author of a number of references cited in this monograph. JF is a member of the speaker's bureau for the following companies: Pfizer, Merck, and Astellas.

Praticien hospitalier

Service de medecine de la Transplantation et d'Immunologie clinique

Hopital Edouard Herriot

Lyon

France

Disclosures

JML has been invited by Astellas, the manufacturer of micafungin, to attend a symposium, and invited by Gilead Sciences, manufacturer of liposomal amphotericin B, to attend different HIV conferences, and has been paid by Gilead Sciences for running HIV educational programs.

Director

Alfa Institute of Biomedical Sciences

Marousi

Athens

Greece

Disclosures

MF declares that he has no competing interests.

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