Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • active symmetric arthritis lasting >6 weeks
  • age 50 to 55 years
  • female gender
  • joint pain
  • joint swelling

Other diagnostic factors

  • morning stiffness
  • swan neck deformity
  • Boutonniere deformity
  • ulnar deviation
  • rheumatoid nodules
  • vasculitic lesions
  • pleuritic chest pain
  • scleritis and/or uveitis

Risk factors

  • genetic predisposition
  • smoking

Diagnostic investigations

1st investigations to order

  • rheumatoid factor (RF)
  • anticyclic citrullinated peptide (anti-CCP) antibody
  • radiographs
Full details

Investigations to consider

  • disease activity score(s)
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Yusuf Yazici

Director

Seligman Center for Advanced Therapeutics

Director

Behcet's Syndrome Evaluation Treatment and Research Center

New York University Hospital for Joint Diseases

New York

NY

Disclosures

YY consults for and receives research support from BMS and Celgene.

Peer reviewers VIEW ALL

Consultant Rheumatologist

Department of Rheumatology

Royal Derby Hospital

Derby

UK

Disclosures

CD has received honoraria for talks at symposia sponsored by Wyeth and Abbott.

Consultant Rheumatologist

Nuffield Orthopaedic Centre

Senior Lecturer in Rheumatology

Botnar Research Centre

University of Oxford

Oxford

UK

Disclosures

RL declares that he has no competing interests.

Professor of Medicine

Section of Rheumatology

University of Wisconsin

Madison

WI

Disclosures

AB has received fees for speaking and consulting from Abbott, BMS, UCB, and Genentech.

Emeritus Professor of Rheumatic Diseases

School of Clinical Sciences

University of Bristol

Bristol

UK

Disclosures

JK declares that he has no competing interests.

Professor of Rheumatology

Arthritis Research UK

Director

Leeds Institute of Rheumatic and Musculoskeletal Medicine

University of Leeds

Director

Leeds Musculoskeletal Biomedical Research Unit

Leeds Teaching Hospitals NHS Trust

Leeds

UK

Disclosures

Not disclosed.

Associate Professor of Medicine

Division of Rheumatology

Washington University School of Medicine

St Louis

MO

Disclosures

PR declares that she has no competing interests.

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