A low-grade vasoformative neoplasm that is associated with human herpesvirus-8 (HHV-8) or Kaposi sarcoma herpesvirus (KSHV) infection.
There are 4 main subtypes: epidemic AIDS-associated Kaposi sarcoma; classic sporadic Kaposi sarcoma; iatrogenic and transplant-associated Kaposi sarcoma; and African endemic Kaposi sarcoma.
Patients may present with multifocal cutaneous lesions, mucosal lesions, or lymph node or visceral involvement.
Therapy is given for symptom palliation, to prevent disease progression, and for cosmetic reasons.
Kaposi sarcoma (KS) is a low-grade vasoformative neoplasm associated with human herpesvirus-8 (HHV-8) or Kaposi sarcoma herpesvirus (KSHV) infection.  Lesions frequently involve mucocutaneous sites, but may become more extensive to involve the lymph nodes and visceral organs. Skin lesions evolve from an early patch, to a plaque, and later to ulcerating tumor nodules.
Professor of Pathology
Director of Cytopathology
University of Pittsburgh Medical Center
LP is an author of some of the studies referenced in this monograph and has also written on Kaposi sarcoma for the following: Decision Support in Medicine; Essential Evidence Plus; Physician's Information & Education Resource; Oxford Desk Reference. He is also a consultant for Omnyx.
Associate Professor of Medicine
Harvard Medical School
Beth Israel Deaconess Medical Center
BJD is an author of some studies referenced in this monograph.
Attending Hematologist and Oncologist
Virginia Mason Clinical Professor of Medicine
University of Washington
Division of Hematology and Oncology
DA is the author of some of the studies referenced in the monograph. DA declares that he has no other competing interests.
Consultant Medical Oncologist/Senior Lecturer
Department of Medical Oncology
Imperial College/Imperial Healthcare NHS Trust
Charing Cross Hospital
JS declares that he has no competing interests.
Department of Dermatology
Erasme University Hospital
TS declares that he has no competing interests.
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