Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • splenomegaly
  • malaise
  • night sweats
  • fever
  • excessive bleeding
  • bone pain

Other diagnostic factors

  • weight loss
  • petechiae, ecchymoses, or easy bruisability
  • infection
  • abdominal pain
  • visual changes
  • focal neurologic signs
  • priapism
  • confusion or stupor

Risk factors

  • hx chronic myelogenous leukemia (CML)
  • exposure to ionizing radiation
  • exposure to alkylating chemotherapeutic agents

Diagnostic investigations

Investigations to consider

  • peripheral smear
  • bone marrow biopsy
  • karyotype
  • fluorescent in situ hybridization (FISH)
  • quantitative PCR
  • serum leukocyte alkaline phosphatase
  • serum vitamin B12
  • T315I gene mutation test
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Carlos Palacio

Professor of Medicine

University of Florida College of Medicine

Jacksonville

FL

Disclosures

CP declares that he has no competing interests.

Associate Professor of Medicine

University of Florida College of Medicine

Jacksonville

FL

Disclosures

FR declares that she has no competing interests.

Peer reviewers VIEW ALL

Assistant Professor of Human Cancer Genetics

Ohio State University

Columbus

OH

Disclosures

DP declares that he has no competing interests.

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