Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • clonus
  • hyper-reflexia

Other diagnostic factors

  • anxiety
  • agitation
  • confusion
  • tremor, shivering, muscle jerking
  • sweating
  • headache
  • tachycardia
  • hypertonia/rigidity
  • diaphoresis
  • flushing
  • dilated pupils
  • hyperthermia
  • myoclonus
  • startling

Risk factors

  • exposure to a serotonergic drug
  • genetic predisposition

Diagnostic investigations

Investigations to consider

  • FBC
  • CPK
  • urine toxicology screen
  • ECG
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Clinical Toxicologist

Calvary Mater Newcastle

Associate Professor

University of Newcastle

Newcastle

Australia

Disclosures

GI is an author of several references cited in this monograph.

Peer reviewers VIEW ALL

Consultant Psychiatrist

East London NHS Foundation Trust

London

UK

Disclosures

KM declares that he has no competing interests.

Chief

Psychiatric Consultation Service

Massachusetts General Hospital

Professor of Psychiatry

Harvard Medical School

Boston

MA

Disclosures

TAS declares that he has no competing interests.

Adjunct Professor

Department of Family and Preventive Medicine

University of Utah

Salt Lake City

UT

Disclosures

PMG declares that he has no competing interests.

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