Last reviewed: November 2017
Last updated: November  2017

Summary

Differentials

Common

  • Alcohol induced
  • Hepatic steatosis
  • Primary biliary cirrhosis
  • Primary sclerosing cholangitis
  • Haemochromatosis
  • Hodgkin's lymphoma
  • Non-Hodgkin's lymphoma (NHL)
  • Waldenström's macroglobulinaemia or lymphoplasmacytic lymphoma
  • Acute myeloid leukaemia (AML)
  • Chronic myeloid leukaemia (CML)
  • Acute lymphocytic leukaemia (ALL)
  • Chronic lymphocytic leukaemia (CLL)
  • Hairy cell leukaemia
  • Myelofibrosis
  • Polycythaemia vera
  • Essential thrombocytosis
  • Splenic metastases
  • Autoimmune haemolytic anaemia
  • Rheumatoid arthritis (RA)
  • Felty's syndrome
  • Systemic lupus erythematosus (SLE)
  • Sarcoidosis
  • Malaria
  • Epstein-Barr virus (EBV)
  • Endocarditis
  • Sepsis-related splenic abscesses
  • Chronic hepatitis C
  • Chronic hepatitis B
  • Sickle cell anaemia
  • Cytoskeletal defects
  • Thalassaemias

Uncommon

  • Benign splenic tumours
  • Portal vein thrombosis
  • Splenic vein thrombosis
  • Budd-Chiari syndrome
  • Haemophagocytic lymphohistiocytosis
  • Amyloidosis
  • Gaucher's or Niemann-Pick disease
  • Splenic rupture
  • Subcapsular haemorrhage
  • Secondary to granulocyte colony-stimulating factor (G-CSF)

Contributors

Authors VIEW ALL

Assistant Professor of Medicine

Section of Hematology

Yale School of Medicine

Smilow Cancer Center at Yale-New Haven

New Haven

CT

Disclosures

TLP declares that she has no competing interests.

Dr Terri L. Parker would like to gratefully acknowledge Dr Alan E. Lichtin, the previous contributor to this monograph. AEL has received research support from Amgen.

Peer reviewers VIEW ALL

Consultant Haematologist

Bristol Haematology and Oncology Centre

Bristol

UK

Disclosures

PM declares that she has no competing interests.

Professor of Medicine

Mayo Clinic

Scottsdale

AZ

Disclosures

RAM declares that he has no competing interests.

Director of the Laboratory of Clinical Epidemiology

IRCCS Policlinico S. Matteo Foundation

Pavia

Italy

Disclosures

GB declares that he has no competing interests.

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