Last reviewed: November 2017
Last updated: November  2017

Summary

Differentials

Common

  • Leukaemia
  • Metastatic malignancy
  • Hodgkin's lymphoma
  • Non-Hodgkin's lymphoma
  • Miliary TB
  • Disseminated intravascular coagulation (DIC)
  • Post-transfusion
  • Haemolysis, elevated liver enzymes, low platelet count (HELLP)
  • Cardiopulmonary bypass
  • Idiopathic thrombocytopenic purpura (ITP)
  • Systemic lupus erythematosus (SLE)
  • Rheumatoid arthritis
  • Antiphospholipid syndrome
  • HIV/AIDS
  • Malaria
  • Cytomegalovirus (CMV)
  • Mononucleosis
  • Sepsis
  • Heparin-induced thrombocytopenia (HIT)
  • Antimalarials, antiepileptic drugs, antibiotics, or chemotherapies
  • Alcohol ingestion
  • B12 deficiency
  • Folate deficiency
  • Gestational thrombocytopenia
  • Cirrhosis

Uncommon

  • Multiple myeloma
  • Bone marrow fibrosis
  • Thrombotic thrombocytopenic purpura (TTP)
  • Haemolytic uraemic syndrome (HUS)
  • Sarcoidosis
  • Cyclic thrombocytopenia
  • Wiskott-Aldrich syndrome
  • May-Hegglin anomaly
  • Bernard-Soulier syndrome
  • Gaucher's disease
  • Hashimoto's thyroiditis
  • Aplastic anaemia
  • Vaccinations
  • Paroxysmal nocturnal haemoglobinuria (PNH)
  • Pseudothrombocytopenia

Contributors

Authors VIEW ALL

Associate Professor

Weill Cornell Medicine

Pathology and Laboratory Medicine

Division of Immunopathology

New York

NY

Disclosures

JTG declares that she has no competing interests.

Dr Julia T. Geyer would like to gratefully acknowledge Dr Alan E. Lichtin, a previous contributor to this monograph. AEL is on an advisory board and has received research support from Amgen.

Peer reviewers VIEW ALL

Clinical Professor of Medicine

University of Texas Health Science Center

San Antonio

Cancer Care Network of South Texas

San Antonio

TX

Disclosures

RML declares that he has no competing interests.

Clinical Assistant Professor of Medicine

University of Connecticut School of Medicine

Farmington

CT

Disclosures

JSW has received research support from Amgen, Ligand Pharmaceuticals, and MGI Pharma for clinical studies in immune thrombocytopenic purpura.

Professor of Medicine

Case Western Reserve University School of Medicine

Cleveland

OH

Disclosures

KRM declares that he has no competing interests.

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