Last reviewed: November 2017
Last updated: November  2017

Summary

Differentials

Common

  • Herpes simplex
  • Herpes zoster (shingles)
  • Varicella zoster, acute (chickenpox)
  • Dermatophyte infections (inflammatory or bullous tinea pedis)
  • Scabies
  • Friction blister
  • Miliaria
  • Eczematous dermatitis (contact, nummular, and pompholytic)
  • Thermal burn
  • Frostbite
  • Impetigo

Uncommon

  • Staphylococcal scalded skin syndrome
  • Epidermolysis bullosa
  • Coma bullae
  • Nutritional deficiencies (zinc, biotin, niacin, essential fatty acids)
  • Porphyria cutanea tarda
  • Pseudo-porphyria cutanea tarda
  • Diabetic bullae (bullosis diabeticorum)
  • Incontinentia pigmenti
  • Bullous ichthyosiform erythroderma (epidermolytic hyper-keratosis)
  • Mastocytosis
  • Bullous arthropod bite reaction
  • Erythema multiforme
  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis
  • Amyloidosis
  • Hand-foot-mouth disease
  • Congenital syphilis
  • Linear IgA disease
  • Chronic bullous disease of childhood
  • Pemphigus vulgaris
  • Pemphigus foliaceus (fogo selvagem, pemphigus erythematosus)
  • Paraneoplastic pemphigus
  • Bullous pemphigoid
  • Pemphigoid gestationis
  • Mucous membrane pemphigoid (cicatricial pemphigoid)
  • Epidermolysis bullosa acquisita
  • Bullous lupus erythematosus
  • Dermatitis herpetiformis

Contributors

Authors VIEW ALL

Assistant Clinical Professor

Departments of Dermatology and Pathology

University of California

Davis Medical Center

Sacramento

CA

Disclosures

KLB declares that she has no competing interests.

Peer reviewers VIEW ALL

Professor of Dermato-Epidemiology

Center of Evidence Based Dermatology

Nottingham University Hospitals

NHS Trust

Queen's Medical Centre

Nottingham

UK

Disclosures

HCW declares that he has no competing interests.

Head of Department

Department of Dermatology

St George Hospital

Conjoint Professor

University of New South Wales

Sydney

Australia

Disclosures

DFM declares that she has no competing interests.

Associate Professor and Clinical Director

Section of Dermatology

University of Chicago

Chicago

IL

Disclosures

VPR declares that she has no competing interests.

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