Chronic inflammatory skin disease characterised by extensive erythematous, circumscribed scaly papules, and plaques.
Runs a variable course and seldom completely subsides. Severity is aggravated by genetic, infectious, emotional, and environmental factors.
Lesions are red, inflamed, silvery-white scaly, and circumscribed papules and plaques on elbows, knees, extensor limbs, and scalp. Psoriatic nails have a pitted surface and/or hypertrophic (subungual) changes.
Diagnosis is usually clinical.
Mild or limited psoriasis is treated with topical corticosteroids and/or vitamin D analogues.
Moderate to severe and/or extensive psoriasis may require phototherapy, oral retinoids, methotrexate, biological agents, or ciclosporin.
Psoriasis is a chronic inflammatory skin disease characterised by erythematous, circumscribed scaly papules, and plaques on elbows, knees, extensor limbs, scalp, and, less commonly, nails, ears, and umbilical region. The disease is typically lifelong, with a fluctuating course of exacerbations and remission. It causes itching, irritation, burning, and stinging in half the cases. Although the classification typically includes psoriatic arthritis, skin manifestations only are discussed in this topic.
Associate Dean, Clinical Research
Director of Clinical Research
Southern California Clinical and Translational Science Institute (CTSI)
Associate Professor of Dermatology
Keck School of Medicine
University of Southern California
AWA is an investigator and consultant for Abbott, Amgen, and Janssen. AWA is also the author of references cited in this monograph.
Dr April W. Armstrong would like to gratefully acknowledge Dr Tsu-Yi Chuang, a previous contributor to this monograph. TC declares that he has no competing interests.
Western Infirmary, Glasgow
Consultant Dermatologist Dermatology
DB is an author of a clinical practice guideline referenced in this monograph. DB has been reimbursed as a consultant, researcher, and lecturer for Abbott, Leo, Pfizer, Merck, Janssen-Cilag, and Novartis.
Department of Dermatology
Kaiser Permanente Vallejo Medical Center
PM declares that she has no competing interests.
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