Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • low-grade fever
  • oral vesicles and ulcers
  • rash and/or vesicles on the palms and soles

Other diagnostic factors

  • malaise
  • sore mouth
  • loss of appetite
  • sore throat
  • rash and/or vesicles on the buttocks
  • abdominal pain
  • diarrhoea
  • cough
  • tongue erythema/oedema
  • arthralgia

Risk factors

  • immunosuppression
  • age <10 years
  • family or school contacts with infection

Diagnostic investigations

Emerging tests

  • PCR molecular assays
Full details

Treatment algorithm

ACUTE

Contributors

Authors VIEW ALL

Consultant Dermatologist

Birmingham Children's Hospital and Birmingham City Hospital

Birmingham

UK

Disclosures

MIO declares that she has no competing interests.

Peer reviewers VIEW ALL

Consultant Paediatrician

Heartlands Hospital

Birmingham

UK

Disclosures

HG declares that she has no competing interests.

Consultant in Paediatric Infectious Diseases and Immunology

Royal Liverpool Children's Hospital (Alder Hey)

Liverpool

UK

Disclosures

AR has been funded by GlaxoSmithKline as a consultant and has been reimbursed by CLB Behring following attendance at a European conference.

Assistant Professor

Department of Pathology and Laboratory Medicine

University of California

Los Angeles

CA

Disclosures

DC declares that he has no competing interests.

Staff Dermatologist

Department of Dermatology

Massachusetts General Hospital

Boston

MA

Disclosures

LI declares that he has no competing interests.

Assistant Professor of Medicine

Associate Residency Program Director

University of Chicago

Chicago

IL

Disclosures

AS declares that she has no competing interests.

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