Last reviewed: November 2017
Last updated: September  2016

Summary

Definition

History and exam

Other diagnostic factors

  • proteinuria
  • hypertension
  • oedema

Risk factors

  • family history of IgAN
  • male sex
  • age 20 to 30 years
  • Asian/white/native American ancestry
  • Henoch-Schönlein purpura (HSP)
  • chronic liver disease
  • HIV infection

Diagnostic investigations

1st investigations to order

  • urinalysis
  • urine microscopy and culture
  • basic biochemistry, including estimated GFR
  • C3 and C4 complement levels
  • renal ultrasound
  • computed tomography (KUB)
  • renal biopsy
Full details

Investigations to consider

  • flexible cystoscopy
  • skin biopsy
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Reader

Department of Infection, Immunity & Inflammation

University of Leicester

Honorary Consultant Nephrologist

John Walls Renal Unit

Leicester General Hospital

Head of the Postgraduate Specialty School of Clinical Academic Training

Health Education East Midlands

UK

Disclosures

JB has consultancies in place with Anthera Pharmaceuticals, Ablynx, Omeros, EMD Serono, and Pharmalink AB. He is also an author of a number of references cited in this monograph.

Adjunct Assistant Professor

Deputy Head & Consultant

Department of Renal Medicine

Tan Tock Seng Hospital

Singapore

Disclosures

SCY is an author of a reference cited in this monograph.

Dr Jonathan Barratt and Dr See Cheng Yeo would like to gratefully acknowledge Dr Hani Bleibel and Dr Chike Nzerue, previous contributors to this monograph. HB and CN declare that they have no competing interests.

Peer reviewers VIEW ALL

Associate Professor of Medicine

Nephrology Division

Stanford University Medical Center

Stanford

CA

Disclosures

RL declares that he has no competing interests.

Professor of Nephrology

UCL Centre for Nephrology

Royal Free Hospital

London

UK

Disclosures

AS declares that he has no competing interests.

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