Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • pruritus
  • tense blisters on normal or erythematous skin

Other diagnostic factors

  • erythematous or urticarial plaques
  • oral lesions

Risk factors

  • age 60 to 90 years
  • major histocompatibility complex (MHC) class II allele (DQB1*0301)
  • male gender

Diagnostic investigations

1st investigations to order

  • skin bx for histopathological evaluation with light microscopy
  • skin bx for direct immunofluorescence testing
  • indirect immunofluorescence test on serum
Full details

Emerging tests

  • immunoblotting
  • immunoprecipitation
  • fluorescence overlay antigen mapping (FOAM) technique
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Associate Professor of Dermatology and Pathology

Director

Dermatopathology Fellowship Program

Section of Dermatology

Department of Medicine

The University of Chicago

Chicago

IL

Disclosures

VPR declares that she has no competing interests.

Peer reviewers VIEW ALL

Clinical Professor of Dermatology and Cutaneous Biology

Director

Jefferson Center for International Dermatology

Jefferson Medical College

Thomas Jefferson University

Philadelphia

PA

Disclosures

LP declares that he has no competing interests.

Assistant Professor of Dermatology

Department of Dermatology

University of Pittsburgh

Pittsburgh

PA

Disclosures

TP declares that he has no competing interests.

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