Last reviewed: October 2017
Last updated: ??display.month.09_en_GB??  2016

Summary

Definition

History and exam

Key diagnostic factors

  • increased predispostion in certain ethnic/geographic groups
  • oral ulcers
  • genital ulcers
  • uveitis
  • acne lesions
  • erythema nodosum
  • short duration of symptoms
  • stroke
  • eye pain, blurry vision, photophobia, or photosensitivity
  • memory loss
  • headache, confusion, or fever
  • haemoptysis, cough, shortness of breath, or chest pain
  • eye redness or tearing
  • impaired speech, balance, or movement
  • superficial thrombophlebitis
  • hypopyon

Other diagnostic factors

  • cramping abdominal pain, diarrhoea, or GI ulceration

Risk factors

  • age 20 to 40 years
  • family history of Behcet's syndrome
  • genetic predisposition

Diagnostic investigations

Investigations to consider

  • pathergy testing
  • RF
  • ANA
  • anti-neutrophil cytoplasmic antibodies
  • HLA-B51
  • MRI, magnetic resonance angiography brain with contrast
  • colonoscopy
  • upper GI endoscopy
  • high-resolution chest CT
  • CT angiography of chest
  • pulmonary angiography
Full details

Emerging tests

  • anti-Saccharomyces cerevisiae antibodies
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Yusuf Yazici

Director

Seligman Center for Advanced Therapeutics

Director

Behcet's Syndrome Evaluation Treatment and Research Center

New York University Hospital for Joint Diseases

NY

Disclosures

YY has received educational grant support from and has acted as a consultant for Celgene, genentech, and BMS.

Peer reviewers VIEW ALL

Associate Professor of Medicine

Department of Rheumatology

Cerrahpasa Medical Faculty

Istanbul

Turkey

Disclosures

IF declares that he has no competing interests.

Assistant Professor of Medicine

Division of Rheumatology and Immunology

Duke University Medical Center

Durham

NC

Disclosures

MEBC has received speaking fees from Abbott Pharmaceuticals.

Assistant Professor of Medicine

Division of Rheumatology

Johns Hopkins University School of Medicine

Co-Director

Johns Hopkins Vasculitis Center

Baltimore

MD

Disclosures

PS declares that he has no competing interests.

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