Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • post-pubertal age
  • positive FHx of Gilbert syndrome
  • icterus (jaundice)
  • absence of hepatosplenomegaly
  • no stigmata of chronic liver disease

Risk factors

  • post-pubertal age
  • FHx of Gilbert syndrome

Diagnostic investigations

1st investigations to order

  • unconjugated bilirubin
  • liver aminotransferases
  • gamma-glutamyl transpeptidase
  • lactate dehydrogenase
  • FBC
  • peripheral blood smear
  • direct Coombs' test
Full details

Investigations to consider

  • liver biopsy
  • plasma unconjugated bilirubin response to fasting
  • plasma unconjugated bilirubin response to nicotinic acid
  • UDPGT-1A1 genotyping
  • UDPGT enzyme activity
Full details

Treatment algorithm

ONGOING

Contributors

Authors VIEW ALL

Assistant Professor of Medicine

Gastroenterology & Hepatology

University of Nebraska Medical Center

Omaha

NE

Disclosures

MAOM declares that he has no competing interests.

Dr Marco A. Olivera-Martinez would like to gratefully acknowledge Dr Brian Ward and Dr John L. Gollan, the previous contributors to this monograph. BW declares that he has no competing interests. JLG is an author of a study referenced in the monograph.

Peer reviewers VIEW ALL

Professor of Pediatrics

Division of Endocrinology and Metabolism

Baylor College of Medicine

Texas Children's Hospital

Houston

TX

Disclosures

LPK declares that she has no competing interests.

Consultant Surgeon

St. Mark's Hospital

London

UK

Disclosures

JTJ declares that he has no competing interests.

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