Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • lymphadenopathy
  • presence of risk factors

Other diagnostic factors

  • unexplained fevers
  • night sweats
  • weight loss
  • dyspnoea
  • cough
  • chest pain
  • superior vena cava syndrome
  • abdominal pain
  • generalised pruritus
  • alcohol-induced pain at involved sites
  • hepatomegaly and/or splenomegaly
  • tonsillar enlargement

Risk factors

  • history of EBV infection
  • family history of Hodgkin's lymphoma
  • young adults from higher socio-economic class
  • HLA types
  • Jewish ancestry

Diagnostic investigations

1st investigations to order

  • FBC with differential
  • metabolic panel
  • ESR
  • CXR
  • PET-CT scan
  • gallium scan
  • contrast CT neck, chest, and abdomen/pelvis
  • excisional lymph node biopsy
  • immunohistochemical studies
Full details

Investigations to consider

  • bone marrow biopsy
  • TFT
  • echocardiogram or multi-gated acquisition (MUGA) scan
  • PFT
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Assistant Attending

Lymphoma Service

Memorial Sloan-Kettering Cancer Center

New York City

NY

Disclosures

AM has received honoraria for serving on advisory boards for Seattle Genetics, BMS, Merck, and Erytech. She has received honoraria from Seattle Genetics and Takeda for educational lectures.

Dr Alison Moskowitz would like to gratefully acknowledge Dr Chris R. Kelsey, Dr Leonard R. Prosnitz, and Dr Timothy M. Zagar, the previous contributors to this monograph. CRK, LRP, and TMZ declare that they have no competing interests.

Peer reviewers VIEW ALL

Radiation Oncologist

Director of Postgraduate Education

Department of Radiation Oncology

Memorial Sloan-Kettering Cancer Center

New York

NY

Disclosures

JY declares that he has no competing interests.

Chief Fellow

Section of Hematology and Oncology

Department of Internal Medicine

Wake Forest University Baptist Medical Center

Winston-Salem

NC

Disclosures

RC declares that she has no competing interests.

Consultant Haematologist

University College London Hospitals

London

UK

Disclosures

KA declares that he has no competing interests.

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