Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • shortness of breath and fatigue
  • lymphadenopathy
  • splenomegaly

Other diagnostic factors

  • presence of risk factors
  • B symptoms
  • recurrent infections
  • petechiae

Risk factors

  • age over 60 years
  • male sex
  • white ethnicity
  • family history of CLL

Diagnostic investigations

1st investigations to order

  • WBC count with differential
  • blood film
  • haemoglobin
  • platelet count
  • flow cytometry
Full details

Investigations to consider

  • fluorescent in situ hybridisation
  • Coombs' test
  • immunoglobulin levels
  • bone marrow aspirate and biopsy
  • CT scan
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Consultant Haematologist

Department of Haematology & Stem Cell Transplantation

Birmingham Heartlands Hospital

Birmingham

UK

Disclosures

VM declares that she received a consultancy fee from Janssen, and a grant from Takeda for the ASH Annual Meeting 2014.

Consultant Haematologist

Department of Haematology & Stem Cell Transplantation

Birmingham Heartlands Hospital

Birmingham

UK

Disclosures

SP declares that he has received consultancy and speaker fees from Janssen, Gilead, AbbVie, Bristol-Myers Squibb, and Takeda.

Dr Vidhya Murthy and Dr Shankaranarayana Paneesha would like to gratefully acknowledge Dr Robert Chen, the previous contributor to this monograph. RC declares that he has no competing interests.

Peer reviewers VIEW ALL

Professor of Medicine

Director

Hematology Malignancies and Blood & Marrow Transplant Program

University of Colorado at Denver and Health Sciences Center

Denver

CO

Disclosures

HM declares that he has no competing interests.

Consultant Haematologist

The Christie Hospital

Manchester

UK

Disclosures

AB has received research support from Celgene and Roche; attended advisory boards for Roche, GSK, and NAPP; has received honoraria for speaking from NAPP, Roche, and Celgene; and received consultancy payments from GSK.

Consultant Haemato-oncologist

Section of Haemato-Oncology

The Institute of Cancer Research

Sutton

UK

Disclosures

DC declares that he has no competing interests.

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