Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • age 20 to 34 years
  • testicular mass

Other diagnostic factors

  • extratesticular manifestation

Risk factors

  • cryptorchidism
  • gonadal dysgenesis
  • FHx of testicular cancer
  • personal hx of testicular cancer
  • testicular atrophy
  • white ethnicity
  • chemical carcinogens and low sperm count
  • rural residence
  • higher socioeconomic status
  • inguinal hernia
  • genetic abnormality of chromosome 12

Diagnostic investigations

1st investigations to order

  • ultrasound (colour Doppler) of testis
  • CT scan (abdomen and pelvis)
  • serum beta-hCG
  • serum alpha-fetoprotein (AFP)
  • serum LDH
Full details

Investigations to consider

  • CXR
  • serum placenta alkaline phosphatase
  • serum gamma-GT
  • MRI scan (abdomen and pelvis)
  • CT scan chest
  • histological examination of testicular mass post-orchiectomy
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Associate Professor of Surgery/Urology

Director of Prostate Cancer Fellowship Program

School of Medicine

University of Colorado Denver

Aurora

CO

Disclosures

ABB declares that he has no competing interests.

Assistant Professor

University of Colorado Denver School of Medicine

University of Colorado Cancer Center

Aurora

CO

Disclosures

ERK declares that she has no competing interests.

Dr Al B. Barqawi and Dr Elizabeth R. Kessler would like to gratefully acknowledge Dr Thomas W. Flaig, a previous contributor to this monograph. TWF declares that he has no competing interests.

Peer reviewers VIEW ALL

Assistant Professor of Medicine and Oncology

Karmanos Cancer Institute

Wayne State University

Detroit

MI

Disclosures

EH declares that she has no competing interests.

Consultant/Honorary Senior Lecturer in Medical Oncology

SW Wales Cancer Institute/Department of Oncology

Singleton Hospital

Sketty

Swansea

UK

Disclosures

GB declares that he has no competing interests.

Senior Lecturer in Medical Oncology

School of Cancer Sciences

University of Birmingham

Birmingham

UK

Disclosures

EP declares that he has no competing interests.

Use of this content is subject to our disclaimer