Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • potential exposure to measles
  • unimmunised or vaccine failure
  • fever
  • cough
  • coryza
  • conjunctivitis
  • Koplik's spots
  • maculopapular rash

Risk factors

  • exposure to measles virus
  • no prior immunisation against measles
  • failure to respond to measles vaccine

Diagnostic investigations

1st investigations to order

  • measles-specific IgM and IgG serology (ELISA)
Full details

Investigations to consider

  • acute and convalescent sera for measles-specific IgG and IgM
  • measles RNA detection by PCR
  • antigen detection by fluorescent antibody or PCR techniques
  • isolation of virus in tissue culture system
Full details

Treatment algorithm

ACUTE

Contributors

Authors VIEW ALL

Professor of Pediatrics

Boston University School of Medicine

Boston Medical Center

Boston

MA

Disclosures

EB is on the speakers' bureau of Merck and GlaxoSmithKline; has received reimbursements from Salix Pharmaceuticals and Novartis for consulting; has received research funding from Valneva (JE vaccine), PaxVax (cholera vaccine), and Cerexa (ceftaroline for pneumonia in children); served on a data safety monitoring board for Pfizer (pneumococcal vaccine); has received royalties from Elsevier (Immigrant Medicine), AAP (Nelson's pediatric antimicrobial therapy), and UptoDate (Immigrant screening); and has received honorarium from PaxVax (cholera vaccine advisory board).

Peer reviewers VIEW ALL

Associate Professor of Pediatrics

West Virginia University School of Medicine

Morgantown

WV

Disclosures

LN is an author of a reference cited in this monograph.

Assistant Professor of Medicine

Associate Residency Program Director

University of Chicago

Chicago

IL

Disclosures

AS declares that she has no competing interests.

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