A rare but severe zoonotic infection caused by a virus of the Filoviridae family (genus Marburgvirus ).
Most common presentation includes high fevers and headache, often with gastrointestinal symptoms (nausea/vomiting). Signs of bleeding are rare and associated with late disease.
Endemic to East and Central Africa and associated with fruit bat, cave, and mining exposure, or close contact with infected persons in the last 21 days.
Highly infectious and transmissible person-to-person by contact with body fluids, contaminated objects, and corpses. High-level isolation precautions must be used when Marburg is suspected.
Diagnosis is made by reverse transcriptase polymerase chain reaction (RT-PCR) from blood or buccal (oral) swab, often by a reference laboratory. A positive test confirms current infection, but a negative test does not rule out infection until symptoms have been present for at least 72 hours.
There is no specific treatment; historical fatality rates have been as high as 90% and, based on recent experience with Ebola, may be improved with aggressive supportive care and fluid resuscitation.
A rare but severe, zoonotic infection caused by an RNA virus of the Filoviridae family (genus Marburgvirus ). It is related to, but distinct from, Ebola virus. It was discovered in 1967 after simultaneous outbreaks in several European laboratories, including one in Marburg, Germany.
The virus is thought to be initially acquired from infected animals such as bats and non-human primates, but can also be spread by human-to-human transmission. Transmission occurs by close contact with body fluids of infected patients. The incubation period after infection is typically 5 to 10 days, although some estimates range from 2 to 26 days.    Human infection carries a case fatality rate of 23% to 90%.  
Marburg virus infection is part of the group of conditions known as viral haemorrhagic fevers. Since Marburg virus infection presents with similar features to Ebola virus, and because there is more information published on Ebola, some general statements and conclusions on the best type of care for Marburg are based on current knowledge of Ebola.  
Infectious Diseases Division
Massachusetts General Hospital
LB is the author of a reference cited in this monograph.
Professor of Epidemiology
University of Nebraska Medical Center
MK declares that he has no competing interests.
Adult and Pediatric Infectious Disease Fellow
VR declares that she has no competing interests.
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