Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • fever ≥37.5°C

Other diagnostic factors

  • headache
  • myalgia
  • arthralgia
  • weakness
  • backache
  • neck stiffness
  • dizziness
  • chills
  • loss of appetite
  • vomiting
  • photophobia
  • pain behind the eyes
  • vision impairment
  • retinitis
  • meningoencephalitis
  • hepatitis
  • acute kidney injury
  • haemorrhagic fever

Risk factors

  • livestock handling through occupational exposure or homestead exposure
  • consuming raw animal fluids or tissue
  • genetic polymorphism
  • advanced age
  • mosquito exposure
  • gender

Diagnostic investigations

1st investigations to order

  • reverse transcriptase-polymerase chain reaction (RT-PCR)
  • serum IgM or IgG detection with ELISA
  • FBC
  • serum electrolytes
  • LFTs
Full details

Investigations to consider

  • coagulation studies
  • serum creatinine and urea
  • creatine phosphokinase (CPK)
Full details

Treatment algorithm

ACUTE

Contributors

Authors VIEW ALL

Associate Professor

Pediatric Infectious Diseases

Stanford University

Bechtel Faculty Scholar

Stanford Child Health Research Institute

Stanford

CA

Disclosures

ADL is the author of several references cited in this monograph.

Laboratory Manager and Research Associate

LaBeaud Lab

Department of Pediatrics - Infectious Disease

Stanford University School of Medicine

Stanford

CA

Disclosures

ENG declares that she has no competing interests.

Peer reviewers VIEW ALL

Assistant Professor

Emory University

Atlanta

GA

Disclosures

AKM receives funding for RVFV-related research from Burroughs Wellcome, NIH, and Children’s Healthcare of Atlanta. AKM consults for Regeneron.

Chairman

Section of Infectious Diseases and Infection Control & Environmental Health unit

Viral Hemorrhagic Fever Scientific Chair

Faculty of Medicine

King Abdulaziz University

Jeddah

Saudi Arabia

Disclosures

TAM is the author of a reference cited in this monograph.

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