Last reviewed: February 2018
Last updated: November  2017



History and exam

Key diagnostic factors

  • presence of risk factors
  • lipaemia retinalis
  • eruptive xanthoma

Other diagnostic factors

  • obesity/overweight
  • diabetes
  • CAD
  • angina/claudication
  • abdominal pain and other features of pancreatitis

Risk factors

  • FHx hyperlipidaemia
  • FHx diabetes
  • overweight/obese patients
  • high-saturated-fat diet
  • high-carbohydrate diet
  • insulin resistance
  • liver disease
  • hypothyroidism
  • renal disease
  • excessive alcohol consumption
  • HIV
  • cystic fibrosis
  • medications
  • Cushing's syndrome
  • acute spinal cord injury
  • inflammatory/immune disorders
  • anorexia nervosa
  • organ transplant

Diagnostic investigations

Investigations to consider

  • TSH
  • fasting plasma glucose
  • urea, creatinine
  • serum albumin
  • LFTs
  • serum protein electrophoresis
  • CT abdomen
Full details

Treatment algorithm


Authors VIEW ALL

Professor of Medicine

VA Greater Los Angeles Healthcare System and UCLA School of Medicine

Los Angeles



DAL is an author of several references cited in this monograph.

Peer reviewers VIEW ALL

Assistant Professor of Medicine

Division of Cardiology

Heart and Vascular Center

Metro Health Medical Center

Case Western Reserve University




MLA declares that he has no competing interests.

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