Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • female of reproductive age
  • irregular menstruation
  • infertility
  • hirsutism

Other diagnostic factors

  • acne
  • overweight or obesity
  • hypertension
  • scalp hair loss
  • oily skin or excessive sweating
  • acanthosis nigricans

Risk factors

  • family history of PCOS
  • premature adrenarche
  • low birth weight
  • fetal androgen exposure
  • obesity
  • environmental endocrine disruptors

Diagnostic investigations

1st investigations to order

  • serum total and free testosterone
  • serum dehydroepiandrosterone sulfate (DHEAS)
  • serum 17-hydroxyprogesterone
  • serum prolactin
  • serum TSH
  • oral glucose tolerance test
  • fasting lipid panel
Full details

Investigations to consider

  • serum androstenedione
  • pelvic ultrasound
  • basal body temperature monitoring
  • luteal phase progesterone measurement
  • serum LH and FSH
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Mark O. Goodarzi

Director

Division of Endocrinology, Diabetes & Metabolism

Professor of Medicine

Cedars-Sinai Medical Center

Los Angeles

CA

Disclosures

MOG is an author of a number of references cited in this monograph.

Peer reviewers VIEW ALL

Professor

Department of Obstetrics and Gynecology

University of California Davis

Sacramento

CA

Disclosures

AD declares that he has no competing interests.

Professor

Department of Obstetrics and Gynecology

Penn State Hershey College of Medicine

Hershey

PA

Disclosures

RSL has been reimbursed by Serono for attending a medical conference and received a lecture fee, and has consulted for Ferring. He has received research funding from the NIH, the Commonwealth of Pennsylvania, and Parke Davis. He is an author of a number of references cited in this monograph.

Gynaecologist/Fertility Specialist

Division of Reproductive Medicine

Department of Obstetrics and Gynaecology

VU University Medical Centre

Amsterdam

The Netherlands

Disclosures

CBL declares that he has no competing interests.

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