Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • family history
  • hx of asbestos exposure
  • age between 60 and 85 years
  • shortness of breath
  • diminished breath sounds
  • dullness to percussion

Other diagnostic factors

  • male sex
  • chest pain
  • cough
  • constitutional symptoms
  • abdominal distension and/or pain

Risk factors

  • asbestos exposure
  • asbestos exposure during home maintenance and renovation
  • age 60 to 85 years
  • male sex
  • radiation exposure
  • genetic predisposition
  • simian virus 40 (SV-40)

Diagnostic investigations

1st investigations to order

  • chest x-ray
  • chest CT scan
Full details

Investigations to consider

  • thoracentesis
  • pleural biopsy
  • video-assisted thoracoscopic surgery (VATS)
  • chest MRI
  • PET scan
  • cervical mediastinoscopy
  • PFT
  • FBC
  • basic metabolic panel
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Staff Clinician

Center for Cancer Research

Thoracic and Gastrointestinal Oncology Branch

National Cancer Institute

Bethesda

MD

Disclosures

AT declares that he has no competing interests.

Medical Oncology Branch

Center for Cancer Research

National Cancer Institute

Bethesda

MD

Disclosures

JdR declares that he has no competing interests.

Nurse Practitioner

Executive Director

Mesothelioma Applied Research Foundation

Alexandria

VA

Disclosures

MH declares that she has no competing interests.

Dr Anish Thomas, Dr Jaydira del Rivero, and Mrs Mary Hesdorffer would like to gratefully acknowledge Dr Robert Taub and Dr Chris R. Kelsey, the previous contributors to this monograph. RT and CRK declare that they have no competing interests.

Peer reviewers VIEW ALL

Associate Professor of Surgery

University of Toronto

Division of Thoracic Surgery

Toronto General Hospital

Ontario

Canada

Disclosures

MdP is an author of a reference cited in this monograph.

Chair and Medical Director

Developmental Therapeutics

Co-Chair

GU Committee

US Oncology Research

Comprehensive Cancer Centers of Nevada

Las Vegas

NV

Disclosures

NJV is a past chair of a US-based mesothelioma foundation. NJV is an author of a number of references cited in this monograph.

Professor of Cardiothoracic Surgery (Honorary)

Clinical Operational Research Unit

Department of Mathematics

University College London

London

UK

Disclosures

TT declares that he has no competing interests.

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