Last reviewed: November 2017
Last updated: May  2016

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • first trimester of pregnancy
  • missed period
  • vaginal bleeding
  • unusually large uterus for gestational age

Other diagnostic factors

  • headache and photophobia
  • shortness of breath and respiratory distress
  • severe nausea and emesis
  • tachycardia, tremor, insomnia, and diarrhoea
  • HTN
  • pallor
  • pelvic pain
  • uterine bleeding
  • peripheral oedema

Risk factors

  • extremes of maternal age
  • prior gestational trophoblastic disease (GTD)
  • blood group A, B, AB
  • tobacco use
  • diminished dietary fat and carotene

Diagnostic investigations

1st investigations to order

  • serum beta hCG
  • FBC
  • serum PT, PTT
  • serum metabolic panel
  • serum TSH
  • blood type with antibody screen
  • pelvic ultrasound
  • CXR
  • histological examination of placental tissue
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Professor

Department of Obstetrics and Gynecology

University of North Carolina

Chapel Hill

NC

Disclosures

JS declares that he has no competing interests.

Assistant Professor

Department of Obstetrics and Gynecology

Indiana University

Indianapolis

IN

Disclosures

ER declares that she has no competing interests.

Peer reviewers VIEW ALL

Consultant Gynecologist

Subspecialist in Reproductive Medicine

Newcastle Fertility Centre at Life

Bioscience Centre

International Centre at Life

Newcastle upon Tyne

UK

Disclosures

JS declares that she has no competing interests.

Consultant in Medical Oncology

Department of Medical Oncology

Charing Cross Hospital

London

UK

Disclosures

PS declares that he has no competing interests.

Physician Consultant

Preventive Medicine

Private Practice

Atlanta

GA

Disclosures

AS declares that she has no competing interests.

Use of this content is subject to our disclaimer