Churg-Strauss syndrome

Summary

  • Rare systemic small-vessel vasculitis associated with asthma and eosinophilia.
  • Classic pathological triad of tissue eosinophilia, granulomatous inflammation, and vasculitis.
  • Associated with perinuclear anti-neutrophil cytoplasmic antibody (p-ANCA), the target antigen of which is myeloperoxidase (MPO).
  • The cornerstone of treatment is corticosteroids. Severe disease is treated in a similar manner to other ANCA-associated vasculitides, with additional immunosuppressive agents.
  • Cardiac involvement causes significant morbidity and mortality.
Last updated: Jan 02, 2013
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