- Endemic mycosis with worldwide distribution caused by the dimorphic fungus Sporothrix schenckii.
- The vast majority of sporotrichosis infections are lymphocutaneous or fixed cutaneous forms, although osteoarticular, pulmonary, meningeal, and disseminated sporotrichosis may occur, especially in patients with diabetes, alcoholism, AIDS, and haematological malignancies, but also in normal hosts.
- Lymphocutaneous sporotrichosis is caused by traumatic inoculation of the fungus into the skin and results in an initial nodular lesion that usually ulcerates, which is followed by ascending nodular lymphangitis.
- The definitive test for diagnosis of lymphocutaneous sporotrichosis is culture of the fungus from skin lesions.
- Because of their non-specific presentation and relative rarity, a high index of clinical suspicion is required for diagnosis of extracutaneous forms of sporotrichosis, which is typically delayed.
- Lymphocutaneous sporotrichosis is not life threatening and responds well to itraconazole treatment.
- Extracutaneous manifestations of sporotrichosis can be life threatening, especially in immunosuppressed patients, and do not always favourably respond to antifungal therapy.
Last updated: May 10, 2013