- Refers to the presence of cryoglobulins in the serum. Cryoglobulins are immunoglobulins that reversibly precipitate at temperatures below 37°C (98.6°F).
- Type I cryoglobulinaemia is mostly associated with lymphoproliferative disorders (e.g., Waldenstrom's macroglobulinaemia); types II and III (mixed cryoglobulinaemia) with autoimmune and infectious conditions, particularly with hepatitis C virus (HCV) infection.
- Clinical presentation includes a triad of purpura, weakness, and arthralgia. Multi-systemic involvement may include the kidneys, liver, and nervous system.
- Diagnosis is based on clinical and laboratory findings. Leukocytoclastic vasculitis is the histological hallmark of mixed cryoglobulinaemia.
- Mixed cryoglobulinaemia secondary to chronic HCV infection includes viral eradication strategies in addition to immunosuppression.
Other related conditions
- Assessment of monoclonal gammopathies
- Monoclonal gammopathy of undetermined significance
- Sjogren's syndrome
- Systemic lupus erythematosus
- Systemic sclerosis (scleroderma)
- Systemic vasculitis
- Multiple myeloma
- Waldenström's macroglobulinaemia
- Chronic lymphocytic leukaemia
- Non-Hodgkin's lymphoma
- Polyarteritis nodosa
- Hodgkin's lymphoma
- Rheumatoid arthritis
- Hepatitis B
- HIV infection
- Infective endocarditis
- Henoch-Schonlein purpura
:به روز شده بتاریخ Thu Jan 17 00:00:00 UTC 2013