- A progressive disorder due to a deficit in both insulin secretion and insulin action, with obesity being the primary cause in children.
- Often asymptomatic and diagnosed by screening in a high-risk individual (e.g., family history, obesity, acanthosis nigricans) or incidentally (e.g., glycosuria found after a school or sports examination).
- The development of insulin resistance and glucose intolerance can be prevented by lifestyle modifications that correct obesity in children.
- Goals of treatment are to promote weight loss and exercise capacity, decrease acanthosis nigricans, normalise glycaemia and HbA1c (goal is <53 mmol/mol [7%]), and prevent long-term complications (e.g., hypertension and dyslipidaemia).
- Treatment includes lifestyle modifications, metformin, and insulin.
Other related conditions
- Acanthosis nigricans
- Obesity in children
- Diabetic cardiovascular disease
- Gestational diabetes mellitus
- Diabetic nephropathy
- Diabetic ketoacidosis
- Essential hypertension
- Inpatient glycaemic management
- Metabolic syndrome
- Overview of diabetes
- Peripheral vascular disease
- Polycystic ovary syndrome
- Chronic renal failure
Last updated: Apr 08, 2013