Summary

• Inherited mechanical fragility of the skin and epithelial tissues.
• Presents as recurrent erosions, blisters, and scars.
• Risk of extracutaneous complications, resulting from recurrent blistering or scarring of tissues.
• Risk of infant or premature death among some epidermolysis bullosa subtypes.
• High risk of death from metastatic squamous cell carcinoma during adulthood in some epidermolysis bullosa subtypes.