- A rare, chronic disease caused by excessive secretion of growth hormone, usually due to a pituitary somatotroph adenoma. It is associated with increased morbidity and premature mortality.
- The diagnosis is often delayed. Early recognition and appropriate treatment are crucial for reducing the potentially debilitating complications of the disease.
- Must be screened for in the presence of acral growth, coarsening of facial features, and when suspected in conjunction with commonly associated conditions, such as carpal tunnel syndrome, arthralgia, glucose intolerance or diabetes, amenorrhoea, HTN, and sleep apnoea.
- Modern surgical and pharmacological modalities are associated with improved outcomes. However, the overall mortality ratio remains increased (1.6-fold compared with the general population).
- Monitoring and treatment of the comorbidities associated with acromegaly are essential for improving the quality of life of patients.
Last updated: Dec 13, 2012