- Huntington's disease is an autosomal dominant neurodegenerative disorder.
- Often presents in mid-life but may appear at any age.
- Clinical manifestations include chorea, cognitive decline, loss of coordination, and personality change.
- Depression and suicide may be comorbid events.
- In the absence of available effective treatment, many at-risk individuals forgo predictive genetic testing.
Last updated: Sep 28, 2012