Summary

• Most commonly presents with painless cervical and/or supraclavicular lymphadenopathy in a young adult.
• B symptoms (fevers, night sweats, weight loss) occur in approximately 30% of patients; more common in advanced disease.
• Imaging, preferably PET-CT, essential to determine extent of disease. Biopsy is necessary to confirm diagnosis.
• Preferred treatment for stage I or stage II Hodgkin's lymphoma (HL) is chemotherapy plus radiotherapy. Chemotherapy is the cornerstone of treatment for patients with stage III or stage IV HL.
• Complications of treatment include secondary malignancies, heart disease, and decreased pulmonary function.