- Most commonly presents as an asymptomatic thyroid nodule detected by palpation or ultrasound in a woman in her 30s or 40s.
- The most important diagnostic test is fine-needle aspiration.
- Treatment is usually total thyroidectomy followed by radioactive iodine ablation and TSH suppression (papillary or follicular).
- Treatment differs and must be tailored for uncommon types of thyroid cancer such as medullary, lymphoma, or anaplastic.
- Prognosis depends on risk-group stratification.