خلاصه

• A human papilloma virus (HPV)-related malignancy, preventable by HPV vaccination, screening, and treatment of high-grade dysplasia.
• Papanicolaou test (Pap smear) screening followed by colposcopy may diagnose pre-invasive disease.
• Locally advanced disease may present with bleeding, discharge, pain, or obstructive uropathy.
• Staging is clinical, and does not incorporate lymph node evaluation or imaging results, but increasingly uses MRI to evaluate local extent of disease, and PET to screen for metastases.
• For pre-invasive disease (i.e., carcinoma in situ) treatment with loop electrosurgical excision procedure or conisation has good cure rates and can preserve fertility.
• For early stage invasive disease, surgery is recommended.
• For locally advanced disease, chemoradiotherapy is significantly superior to radiotherapy alone.