Summary

• Third leading cause of cancer mortality in the US.
• Uncommon in men aged <50 years.
• PSA and digital rectal examination are key diagnostic tools used in screening.
• Management may be expectant or definitive.
• The overall 5-year relative survival rate for 1999 to 2005 was 97%, but this varies greatly depending on National Comprehensive Cancer Network (NCCN) risk category.