Summary

• Chronic inflammatory and auto-immune disorder characterised by diminished lacrimal and salivary gland secretion (sicca complex).
• May present with fatigue and dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia).
• Diagnosed by positive ANAs, anti-60 kD (SS-A) Ro and anti-La auto-antibodies, decreased saliva and tear production, lymphocytic infiltration in labial salivary gland biopsy.
• Treatment mainly symptomatic.