Summary

• A low-grade vasoformative neoplasm that is associated with human herpesvirus-8 (HHV-8) or Kaposi's sarcoma herpesvirus (KSHV) infection.
• There are 4 main subtypes: epidemic AIDS-associated Kaposi's sarcoma; classic sporadic Kaposi's sarcoma; iatrogenic and transplant-associated Kaposi's sarcoma; and African endemic Kaposi's sarcoma.
• Patients may present with multifocal cutaneous lesions, mucosal lesions, lymph node, or visceral involvement.
• Therapy is given for symptom palliation, to prevent disease progression, and for cosmetic reasons.