- An acute encephalopathy with hepatic dysfunction stemming from mitochondrial damage.
- Aetiology remains unknown, but viral infections, exogenous toxins, drugs, and inborn errors of metabolism have been implicated. Aspirin is classically associated but data are lacking for a definitive cause-effect relationship.
- Usually presents after a preceding viral infection with acute onset of profuse vomiting and altered mental status ranging from a personality change to coma.
- Laboratory findings include elevated ammonia, ALT/AST, and prolonged PT, without an increase in bilirubin. Liver biopsy shows steatosis without significant inflammation.
- Treatment includes intensive supportive care, correction of metabolic abnormalities, and control of intracranial pressure.
- Prognosis is generally good, and liver function returns to normal. However, encephalopathy can result in permanent neurological sequelae.
Other related conditions
- Non-diabetic hypoglycaemia
- Assessment of metabolic acidosis
- Overview of seizure disorder
- Respiratory failure
- Type I glycogen storage disease
- Assessment of traumatic brain injury, acute
- Bacterial meningitis
- Viral meningitis
- Paracetamol overdose
- Salicylate poisoning
- Diabetic ketoacidosis
最後更新於: 十月 23, 2012