- Rare disease associated with jaundice, coagulopathy, and hepatic encephalopathy.
- The aetiology and the interval from onset of jaundice to the development of encephalopathy have a significant impact on prognosis.
- Aetiology is established by history, serological assays, and exclusion of alternative causes, including acute presentations of chronic liver diseases.
- Treatment involves ICU monitoring, specific therapies based on aetiology, and management of known complications.
- All patients should be considered for possible liver transplantation.
- Prognostic models may be used to assess the probability of spontaneous recovery and are instrumental in selection of patients who should potentially undergo liver transplantation.
Last updated: May 10, 2013