Acne vulgaris

Differential diagnosis

Differential Diagnosis table forAcne vulgaris
ConditionDifferentiating signs/symptomsDifferentiating tests
Acne keloidalis nuchae
  • Most often seen in black patients; lesions are typically localised to the posterior neck. They begin as papules and pustules and may progress to confluent keloids. [24]

  • Clinical differentiation usually suffices.

Acneiform eruptions
  • Possible aetiologies to consider include oral medicines, topical corticosteroids, contrast dye, testosterone, and cosmetic products.

  • Clinical clues include the abrupt onset of lesions within days of exposure, widespread involvement, atypical locations, atypical age, and improvement with cessation of medicine or exposure.

  • Clinical diagnosis usually suffices.

Chloracne
  • Comedones, pustules, and cysts are most commonly found behind the ears and in the axillae and groin.

  • Consider exposure to halogenated aromatic hydrocarbons (e.g., chlorinated dioxins and dibenzofurans). Patient may have systemic complications such as ophthalmic, neuropathic, hepatic, and lipoprotein abnormalities. [25]

  • Clinical differentiation usually suffices.

  • Consider laboratory tests such as liver enzymes and lipid panel.

Favre-Racouchot syndrome
  • Multiple open and closed comedones on the peri-orbital and malar areas, usually on older people with significant chronic sun exposure. Typically non-inflammatory.

  • Clinical differentiation usually suffices.

  • Skin biopsy shows increased elastic tissue with thickened, tortuous fibres in the upper and mid-dermis. [26]

Folliculitis (non-gram-negative)
  • Common condition that manifests as erythematous papules and pustules, which are follicularly based.

  • As opposed to acne, folliculitis often affects the trunk and extremities.

  • Clinical differentiation usually suffices.

  • Pustular lesions that do not respond to typical acne antibiotics may be cultured.

Gram-negative folliculitis
  • Occurs in patients with acne treated with long-term antibiotics who subsequently develop pustules or nodules on the anterior nares, which then spreads. Can also occur in people after hot tub immersion, as well as in HIV patients.

  • Lesions may be cultured to isolate the gram-negative bacteria if acneiform lesions do not respond to typical antibiotic regimen.

Lupus miliaris disseminatus faciei
  • Firm yellowish-brown or red smooth papules peri-orbitally and characteristically on the eyelid skin. [27]

  • Diascopy reveals yellowish-brown lesions. Skin biopsy reveals caseating epithelioid cell granulomas.

Milia
  • White keratinaceous cysts that are found on the face, particularly on the eyelids. Lesions are fixed and persistent.

  • Skin biopsy shows small cysts derived from the infundibulum of the vellus hair.

Peri-oral dermatitis
  • Common peri-oral eruption of papules and pustules on an erythematous and/or scaling base, often the result of topical corticosteroid use. Localised symmetrically around the mouth, with a clear zone around the vermilion border. [28]

  • Clinical differentiation usually suffices.

Pyoderma faciale
  • Rapid onset of reddish or cyanotic erythema with abscesses, cysts, and occasionally sinus tracts. No comedones and no involvement of back or chest. [29]

  • Skin biopsy shows a grenz zone and mixed inflammatory infiltrate in the upper and mid-dermis, with extravasation of RBCs and haemosiderin deposition.

Rosacea
  • Typically affects older people than acne vulgaris, most often women aged 30 to 50 years.

  • Various forms, but classically presents with background erythema and telangiectasias, and inflammatory papules and pustules occasionally superimposed.

  • Environmental factors often act as triggers.

  • Clinical differentiation usually suffices.

Syringoma
  • Non-inflammatory small papules that occur primarily on the eyelids and upper cheeks, usually multiple.

  • Disproportionately more prevalent in Japanese women.

  • Skin biopsy shows a dense fibrous stroma with dilated cystic spaces that have small comma-like tails resembling tadpoles.

Adenoma sebaceum (angiofibromas)
  • Small, translucent, waxy papules distributed symmetrically over the central cheek, nose, and forehead.

  • Multiple lesions associated with tuberous sclerosis. [30]

  • Skin biopsy shows dermal fibrosis and vascular proliferation and dilation.

最后更新于: 十月 15, 2012
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